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Gallbladder cancer

MedGen UID:
57784
•Concept ID:
C0153452
•
Neoplastic Process
Synonyms: Bladder Cancer, Gall; Bladder Cancers, Gall; Cancer of Gallbladder; Cancer of the Gallbladder; Cancer, Gall Bladder; Cancer, Gallbladder; Cancers, Gall Bladder; Cancers, Gallbladder; Gall Bladder Cancer; Gall Bladder Cancers; Gallbladder Cancer; Gallbladder Cancers
SNOMED CT: Gallbladder Ca (363353009); Malignant tumor of gallbladder (363353009)
 
Monarch Initiative: MONDO:0005411

Definition

A primary or metastatic malignant neoplasm that affects the gallbladder. Representative examples include carcinoma, lymphoma, melanoma, and sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Gallbladder cancer

Professional guidelines

PubMed

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Management of Incidentally Detected Gallbladder Polyps: Society of Radiologists in Ultrasound Consensus Conference Recommendations.
Kamaya A, Fung C, Szpakowski JL, Fetzer DT, Walsh AJ, Alimi Y, Bingham DB, Corwin MT, Dahiya N, Gabriel H, Park WG, Porembka MR, Rodgers SK, Tublin ME, Yuan X, Zhang Y, Middleton WD
Radiology 2022 Nov;305(2):277-289. Epub 2022 Jul 5 doi: 10.1148/radiol.213079. PMID: 35787200
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Biliary Tract Cancers, 2024

Recent clinical studies

Etiology

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Epidemiology of gallbladder cancer in India.
Dutta U, Bush N, Kalsi D, Popli P, Kapoor VK
Chin Clin Oncol 2019 Aug;8(4):33. doi: 10.21037/cco.2019.08.03. PMID: 31484488
Gallbladder cancer: epidemiology and genetic risk associations.
Schmidt MA, Marcano-Bonilla L, Roberts LR
Chin Clin Oncol 2019 Aug;8(4):31. doi: 10.21037/cco.2019.08.13. PMID: 31484487
Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.
Sharma A, Sharma KL, Gupta A, Yadav A, Kumar A
World J Gastroenterol 2017 Jun 14;23(22):3978-3998. doi: 10.3748/wjg.v23.i22.3978. PMID: 28652652Free PMC Article
Gallbladder cancer.
Wernberg JA, Lucarelli DD
Surg Clin North Am 2014 Apr;94(2):343-60. Epub 2014 Feb 18 doi: 10.1016/j.suc.2014.01.009. PMID: 24679425

Diagnosis

Current management of incidental gallbladder cancer: A review.
Feo CF, Ginesu GC, Fancellu A, Perra T, Ninniri C, Deiana G, Scanu AM, Porcu A
Int J Surg 2022 Feb;98:106234. Epub 2022 Jan 21 doi: 10.1016/j.ijsu.2022.106234. PMID: 35074510
Gallbladder Disorders: A Comprehensive Review.
Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T
Dis Mon 2021 Jul;67(7):101130. Epub 2021 Jan 18 doi: 10.1016/j.disamonth.2021.101130. PMID: 33478678
Gallbladder cancer: epidemiology and genetic risk associations.
Schmidt MA, Marcano-Bonilla L, Roberts LR
Chin Clin Oncol 2019 Aug;8(4):31. doi: 10.21037/cco.2019.08.13. PMID: 31484487
Gallbladder Cancer: Diagnosis, Surgical Management, and Adjuvant Therapies.
Hickman L, Contreras C
Surg Clin North Am 2019 Apr;99(2):337-355. doi: 10.1016/j.suc.2018.12.008. PMID: 30846038
Gallbladder cancer.
Wernberg JA, Lucarelli DD
Surg Clin North Am 2014 Apr;94(2):343-60. Epub 2014 Feb 18 doi: 10.1016/j.suc.2014.01.009. PMID: 24679425

Therapy

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Spicy Food and Chili Peppers and Multiple Health Outcomes: Umbrella Review.
Ao Z, Huang Z, Liu H
Mol Nutr Food Res 2022 Dec;66(23):e2200167. Epub 2022 Oct 19 doi: 10.1002/mnfr.202200167. PMID: 36111960Free PMC Article
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
New Horizons for Precision Medicine in Biliary Tract Cancers.
Valle JW, Lamarca A, Goyal L, Barriuso J, Zhu AX
Cancer Discov 2017 Sep;7(9):943-962. Epub 2017 Aug 17 doi: 10.1158/2159-8290.CD-17-0245. PMID: 28818953Free PMC Article
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J; ABC-02 Trial Investigators
N Engl J Med 2010 Apr 8;362(14):1273-81. doi: 10.1056/NEJMoa0908721. PMID: 20375404

Prognosis

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single-cell RNA sequencing.
Chen P, Wang Y, Li J, Bo X, Wang J, Nan L, Wang C, Ba Q, Liu H, Wang H
Clin Transl Med 2021 Jun;11(6):e462. doi: 10.1002/ctm2.462. PMID: 34185421Free PMC Article
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
How Should Gallbladder Cancer Be Managed?
Sachs TE, Akintorin O, Tseng J
Adv Surg 2018 Sep;52(1):89-100. Epub 2018 Jun 25 doi: 10.1016/j.yasu.2018.04.003. PMID: 30098623

Clinical prediction guides

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Genetic characteristics and clinical-specific survival prediction in elderly patients with gallbladder cancer: a genetic and population-based study.
Zhou H, Chen J, Jin H, Liu K
Front Endocrinol (Lausanne) 2023;14:1159235. Epub 2023 Apr 21 doi: 10.3389/fendo.2023.1159235. PMID: 37152947Free PMC Article
Can We Predict Surgical Futility/Cure in Gallbladder Cancer?
Grotz T
Ann Surg Oncol 2022 Sep;29(9):5355-5356. Epub 2022 Jun 7 doi: 10.1245/s10434-022-11985-4. PMID: 35672629
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Shen H, He M, Lin R, Zhan M, Xu S, Huang X, Xu C, Chen W, Yao Y, Mohan M, Wang J
J Exp Clin Cancer Res 2019 Jun 10;38(1):247. doi: 10.1186/s13046-019-1250-8. PMID: 31182136Free PMC Article

Recent systematic reviews

Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis.
Frega G, Cossio FP, Banales JM, Cardinale V, Macias RIR, Braconi C, Lamarca A
Cells 2023 Aug 19;12(16) doi: 10.3390/cells12162098. PMID: 37626908Free PMC Article
Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Wogonin and its analogs for the prevention and treatment of cancer: A systematic review.
Banik K, Khatoon E, Harsha C, Rana V, Parama D, Thakur KK, Bishayee A, Kunnumakkara AB
Phytother Res 2022 May;36(5):1854-1883. Epub 2022 Jan 31 doi: 10.1002/ptr.7386. PMID: 35102626
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis.
Azizi AA, Lamarca A, McNamara MG, Valle JW
Crit Rev Oncol Hematol 2021 Jul;163:103328. Epub 2021 Apr 20 doi: 10.1016/j.critrevonc.2021.103328. PMID: 33862244
Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis.
Xie F, You Y, Huang J, Guan C, Chen Z, Fang M, Yao F, Han J
J Sport Health Sci 2021 Jan;10(1):4-13. Epub 2020 Sep 30 doi: 10.1016/j.jshs.2020.09.009. PMID: 33010525Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Biliary Tract Cancers, 2024

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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